Utilizing solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we look for to unravel the mechanistic facets of the composition and dynamics of chromosomes. Our investigate interests contain:
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‘It was merely a matter of picking up a book on mobile biology and starting to study. I'd originate from a globe of extremely-significant vacuums, cryostats and quantum phenomena, and now I used to be Functioning at room temperature with molecular biology kits.
Given that 2000, Dekker has shifted the most crucial concentrate of his get the job done towards biophysics the place he experiments the Attributes of one biomolecules and cells using the equipment of nanotechnology. This alteration of area was driven by his fascination for that remarkable functioning of biological molecular constructions, and by the extended-expression point of view that numerous interesting discoveries could be predicted in this area.[five] Current lines of study in his biophysics group are inside the regions of:[six]
Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever layout in 2005. (nl)
The coiled-coil from the human Rad50 DNA restore protein incorporates distinct segments of elevated adaptability
All parameters had been precisely the same for every panel During this video, except for the Preliminary placement in the 6hb rod (demonstrated in blue) about the nanopore. Simulations that terminated early as a consequence of translocation of your rod through the pore are marked by a grey background.
Studying DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
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‘The fantastically subtle way by which elements in mother nature operate never ever ceases to amaze me. If we remedy the puzzle of how lifestyle arrived into staying, I assume that my amazement on the complexity of creation should have enhanced and with it my awe for your greatness of the Creator.’
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Lots of new phenomena ended up identified, and he and his research team proven a number one posture With this area of investigate. Dekker and his investigation team uncovered new physics of nanotubes and also explored the feasibility of molecular cees dekker electronics. In 1998, they had been the primary to construct a transistor according to just one nanotube molecule.
One example is, we think about the nucleopore advanced, a gateway concerning the mobile nucleus plus the cytoplasm. This is an extremely complex method and thus difficult to analyze in the cell, so we use biomimetics. We reconstruct holes after which you can insert particular person aspects in the nucleopore complicated to check transport through it at The one-molecule degree.’
Eventually, I'll briefly sketch many of our ideas to discover the creating of synthetic cells, exclusively our initially steps to establish synthetic cell division.